<?xml version="1.0" encoding="UTF-8"?>
<rss xmlns:dc="http://purl.org/dc/elements/1.1/" version="2.0"><channel><atom:link rel="hub" href="http://tumblr.superfeedr.com/" xmlns:atom="http://www.w3.org/2005/Atom"/><description>I am a writer pushing 30 who is trying to finish, well…everything.  I write both original fiction and fanworks, and I belong to a million fandoms.  I am an avid multi-shipper, and I adore crossovers more than most other fanworks.  I identify as a queer female most of the time, though I tend to prefer men to women on average.  I often turn into a ball of righteous feminist rage, and release rants at the speed of light.  Actually, I rant a lot.  About everything.  So, be warned.  My biggest fandom spaces are probably Glee, the Whedonverse, the Whoniverse, and Harry Potter.  I also like obscure science fiction shows from the 90s.</description><title>A Joyful Tyrant</title><generator>Tumblr (3.0; @joyfultyrannous)</generator><link>http://joyfultyrannous.tumblr.com/</link><item><title>Bad Author: Joyful</title><description>&lt;p&gt;&lt;a href="http://fuckyeahbadgleefic.tumblr.com/post/12762505955/bad-author-joyful" class="tumblr_blog"&gt;fuckyeahbadgleefic&lt;/a&gt;:&lt;/p&gt;

&lt;blockquote&gt;
&lt;p&gt;&lt;em&gt;Joyful filled your prompt&lt;/em&gt;&lt;em&gt;, the angst is come&lt;/em&gt;&lt;br/&gt;&lt;em&gt;But really, there’s no joy,&lt;/em&gt;&lt;br/&gt;&lt;em&gt;With rape and drugs, mental health and AIDS&lt;/em&gt;&lt;br/&gt;&lt;em&gt;Repeat there is no joy,&lt;/em&gt;&lt;br/&gt;&lt;em&gt;Repeat there is no joy,&lt;/em&gt;&lt;br/&gt;&lt;em&gt;Repeat, repeat, there is no joy&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;Let us introduce you to the wonders of Joyful, who has the most ironic name in fandom, aside from hyperemmalawlz. &lt;/p&gt;
&lt;p&gt;&lt;a href="http://fuckyeahbadgleefic.tumblr.com/post/12762505955/bad-author-joyful"&gt;Read More&lt;/a&gt;&lt;/p&gt;&lt;/blockquote&gt;



&lt;p&gt;So, I just read this, and I have 2 things to say:&lt;/p&gt;
&lt;p&gt;1) Joyful is my real name.  You can call me Joy, if you want.&lt;/p&gt;
&lt;p&gt;2) I laughed my ass off.  Because this is 100% true.  Before hate drove me off the Internet I wasn&amp;#8217;t a good writer, just a prolific one.  I&amp;#8217;ve gotten better, and I use betas now (yay).  I also publish under a completely different penname as a way to escape the wank.  But back in the day my writing sucked.  I was in a horrible place in my life and all I wrote was angst.  And it wasn&amp;#8217;t even good angst.  It was horrible.  But writing is about getting better, right?&lt;/p&gt;

&lt;p&gt;So, I have no clue how long ago this was written, I haven&amp;#8217;t looked myself up in a very, very long time, for my own mental health.  But no hard feelings, guys.  My writing was pretty bad.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/48217280801</link><guid>http://joyfultyrannous.tumblr.com/post/48217280801</guid><pubDate>Wed, 17 Apr 2013 15:47:39 -0400</pubDate></item><item><title>Hey.
So, I&amp;#8217;m delurking for all of 10 minutes to talk about Tumblr user...</title><description>&lt;p&gt;Hey.&lt;/p&gt;
&lt;p&gt;So, I&amp;#8217;m delurking for all of 10 minutes to talk about Tumblr user CassieValentine.&lt;/p&gt;
&lt;p&gt;I&amp;#8217;ve never actually talked to her. I&amp;#8217;ve never read her fics or headcanons. While I&amp;#8217;m a Castle fan, I&amp;#8217;m not active in the fandom. There aren&amp;#8217;t many fandoms I&amp;#8217;m comfortable being active in anymore. So, I&amp;#8217;m not familiar with the caliber of Cassievalentine&amp;#8217;s fanworks. I don&amp;#8217;t know what she ships, or what tropes she enjoys.&lt;/p&gt;
&lt;p&gt;But here&amp;#8217;s what I do know:&lt;/p&gt;
&lt;p&gt;Some people in the Castle fandom are currently doing to CassieValentine what some people in Glee fandom did to me. They&amp;#8217;re ganging up on her, anonymously, sending her hate. They&amp;#8217;re even enlisting total strangers to try and drive her out of the fandom. They&amp;#8217;re not giving her constructive criticism, they&amp;#8217;re insulting her writing and they&amp;#8217;re attacking her personally.&lt;/p&gt;
&lt;p&gt;THIS IS NOT OKAY.&lt;/p&gt;
&lt;p&gt;It wasn&amp;#8217;t okay two years ago when I got death threats and &amp;#8220;go kill yourself&amp;#8221; messages just because people didn&amp;#8217;t like my Glee fic, and it&amp;#8217;s not okay that it&amp;#8217;s happening to Cassie now.&lt;/p&gt;
&lt;p&gt;This member our tumblr family is suicidal. Not because of pressures from the outside world, but because of what people within the community are doing to her.&lt;/p&gt;
&lt;p&gt;THIS IS NOT OKAY.&lt;/p&gt;
&lt;p&gt;So, before I hide back behind my rock and go back to lurking (because the internet hasn&amp;#8217;t been safe for me for a long time), I&amp;#8217;m gonna say, why don&amp;#8217;t you pop over to CassieValentine&amp;#8217;s tumblr and give her a hug. &amp;#8216;Cause God knows she could use some positive messages. When I was going through the worst of it, the occasional positive ask was often the only thing that kept me going.&lt;/p&gt;
&lt;p&gt;Fandom is cruel. Fans are cruel. It shouldn&amp;#8217;t be that way, but that&amp;#8217;s the way it is. If you can survive being in a fandom, you can do anything.&lt;/p&gt;
&lt;p&gt;The best of luck to you CassieValentine. If you want to correspond with somebody who knows what you&amp;#8217;re going through, feel free to contact me privately.&lt;/p&gt;
&lt;p&gt;Shame on you, Castle fandom. Rick Castle and Kate Beckett would be deeply disappointed in you.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/40875121514</link><guid>http://joyfultyrannous.tumblr.com/post/40875121514</guid><pubDate>Fri, 18 Jan 2013 18:16:42 -0500</pubDate><category>cassievalentine</category><category>castle</category><category>suicide</category><category>trigger warning</category><category>anon hate</category><category>fandom wank</category><category>glee</category></item><item><title>Did you write tonight's episode of Glee or what?</title><description>&lt;p&gt;I don’t really watch Glee anymore.  What happened???&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/37895634540</link><guid>http://joyfultyrannous.tumblr.com/post/37895634540</guid><pubDate>Fri, 14 Dec 2012 02:05:37 -0500</pubDate></item><item><title>So, it&amp;#8217;s like, my birthday or something.  w00t.  Or somesuch.  Bring forward the celebratory...</title><description>&lt;p&gt;So, it&amp;#8217;s like, my birthday or something.  w00t.  Or somesuch.  Bring forward the celebratory noms.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/37650904300</link><guid>http://joyfultyrannous.tumblr.com/post/37650904300</guid><pubDate>Mon, 10 Dec 2012 14:10:05 -0500</pubDate></item><item><title>sevenlittledevils:

I am out of words besides amazing.
</title><description>&lt;img src="http://25.media.tumblr.com/tumblr_mcxj6uBOZQ1r9frlzo2_500.jpg"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://24.media.tumblr.com/tumblr_mcxj6uBOZQ1r9frlzo1_500.jpg"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;p&gt;&lt;a class="tumblr_blog" href="http://sevenlittledevils.tumblr.com/post/34995310646/i-am-out-of-words-besides-amazing"&gt;sevenlittledevils&lt;/a&gt;:&lt;/p&gt;
&lt;blockquote&gt;
&lt;p&gt;I am out of words besides amazing.&lt;/p&gt;
&lt;/blockquote&gt;</description><link>http://joyfultyrannous.tumblr.com/post/34996865206</link><guid>http://joyfultyrannous.tumblr.com/post/34996865206</guid><pubDate>Sun, 04 Nov 2012 14:20:18 -0500</pubDate></item><item><title>You may have noticed but I'm not really on here much anymore.</title><description>&lt;p&gt;I&amp;#8217;m still on tumblr and livejournal and youtube and AO3 and everywhere else, I just have an alternate internet identity, and I also lurk a lot.&lt;/p&gt;
&lt;p&gt;Unfortunately there&amp;#8217;s no real way to announce my alternate screenname to all my casual acquaintances and readers without also announcing it to the bullies and the people who send me hate. Some of them already know, of course, but I&amp;#8217;d like to avoid another flood of &amp;#8220;go kill yourself&amp;#8221; mail if possible.&lt;/p&gt;
&lt;p&gt;If you contact me privately I&amp;#8217;ll let you know where you can find me now.&lt;/p&gt;
&lt;p&gt;I am really sorry about all the fics I will probably never finish. Maybe someday?&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/34996460251</link><guid>http://joyfultyrannous.tumblr.com/post/34996460251</guid><pubDate>Sun, 04 Nov 2012 14:15:08 -0500</pubDate></item><item><title>Seeing as it's author appreciation day, and you're one of my favorite fanfic authors of all time, it only seemed right to send you something :) You were one of my first followers, and still the most major one to date. You're a really, really good person, and I'm horrified how people treated you for DWtWiE. It was tragic, but beautifully done, and one of my favorite fanfictions... ever. I just really like you, and I wish everyone felt the same way.</title><description>&lt;p&gt;Thank you very, very much.  *hug*&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/34995739575</link><guid>http://joyfultyrannous.tumblr.com/post/34995739575</guid><pubDate>Sun, 04 Nov 2012 14:05:48 -0500</pubDate></item><item><title>JoyfulTyrannous</title><description>&lt;p&gt;&lt;a class="tumblr_blog" href="http://glitterdammerung.tumblr.com/post/34861605382/joyfultyrannous"&gt;glitterdammerung&lt;/a&gt;:&lt;/p&gt;
&lt;blockquote&gt;
&lt;p&gt;Joyful has basically been run out of the Glee fandom and off of her internet identity, which is awful and ridiculous because she’s always struck me as a lovely person who gave hateful people a lot more logic and patience than they deserved.&lt;/p&gt;
&lt;p&gt;She wrote ‘Down Where The World Is Ending’ which was the first fic to make me flat out ugly cry. It was beautiful and terrible and it really is just such a well written piece, it’s a crying shame people say such awful things about it.&lt;/p&gt;
&lt;p&gt;The great thing about life - what makes it LIFE - is that it IS beautiful and terrible. It’s not a fairy tale. It’s not all candyfloss and gummi bears. But there is, as Imogen Heap says, beauty in the breakdown, and Joy caught the deepest essence of that in DWTWIE, as painful as that was to read. I admire her ability and willingness to chase into the dark corners and emerge with something that is hard to read but is worth the hurt.&lt;/p&gt;
&lt;p&gt;Here’s to you, Joy.&lt;/p&gt;
&lt;/blockquote&gt;
&lt;p&gt;I am legitimately crying right now.&lt;/p&gt;
&lt;p&gt;Thank you very much for this, really.&lt;/p&gt;
&lt;p&gt;I&amp;#8217;ve been really depressed.  In fact I&amp;#8217;m depressed a lot.  I really, really needed this.&lt;/p&gt;
&lt;p&gt;Thanks.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/34865292638</link><guid>http://joyfultyrannous.tumblr.com/post/34865292638</guid><pubDate>Fri, 02 Nov 2012 20:30:29 -0400</pubDate></item><item><title>Photo</title><description>&lt;img src="http://25.media.tumblr.com/tumblr_mb0tup2yEY1qgyzvzo1_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://24.media.tumblr.com/tumblr_mb0tup2yEY1qgyzvzo2_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://24.media.tumblr.com/tumblr_mb0tup2yEY1qgyzvzo4_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://25.media.tumblr.com/tumblr_mb0tup2yEY1qgyzvzo3_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;</description><link>http://joyfultyrannous.tumblr.com/post/33926138934</link><guid>http://joyfultyrannous.tumblr.com/post/33926138934</guid><pubDate>Fri, 19 Oct 2012 20:42:29 -0400</pubDate></item><item><title>Could you link me to Everything You've Done Wrong?</title><description>&lt;p&gt;&lt;a href="http://www.fanfiction.net/s/1489593/1/Everything_Youve_Done_Wrong"&gt;Everything You’ve Done Wrong&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href="http://eydw-universe.livejournal.com/profile"&gt;EYDW universe&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;:D&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/30943104512</link><guid>http://joyfultyrannous.tumblr.com/post/30943104512</guid><pubDate>Wed, 05 Sep 2012 14:39:45 -0400</pubDate></item><item><title>romulusthread:

people who say madge isn’t important
</title><description>&lt;p&gt;&lt;a href="http://romulusthread.tumblr.com/post/29851399448" class="tumblr_blog"&gt;romulusthread&lt;/a&gt;:&lt;/p&gt;

&lt;blockquote&gt;&lt;p&gt;people who say madge isn’t important&lt;/p&gt;
&lt;p&gt;&lt;img src="http://media.tumblr.com/tumblr_m92pswdvgp1r1vlgo.png"/&gt;&lt;/p&gt;&lt;/blockquote&gt;</description><link>http://joyfultyrannous.tumblr.com/post/29854851447</link><guid>http://joyfultyrannous.tumblr.com/post/29854851447</guid><pubDate>Mon, 20 Aug 2012 18:37:52 -0400</pubDate></item><item><title>Acey-Gleek-Girl has forbidden me from filling it.</title><description>&lt;p&gt;Acey-Gleek-Girl has forbidden me from filling it.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/29784445037</link><guid>http://joyfultyrannous.tumblr.com/post/29784445037</guid><pubDate>Sun, 19 Aug 2012 18:18:12 -0400</pubDate></item><item><title>So I just went on the Teen Wolf Kink Meme</title><description>&lt;p&gt;And the first prompt I found was an AU in which Stiles&amp;#8217; mom died of Huntington&amp;#8217;s Disease.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/29784398956</link><guid>http://joyfultyrannous.tumblr.com/post/29784398956</guid><pubDate>Sun, 19 Aug 2012 18:17:30 -0400</pubDate></item><item><title>You're a sweetie (ﾉ◕ヮ◕)ﾉ*:・ﾟ✧</title><description>&lt;p&gt;thank you, nonny!&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/27788766793</link><guid>http://joyfultyrannous.tumblr.com/post/27788766793</guid><pubDate>Sun, 22 Jul 2012 18:23:28 -0400</pubDate></item><item><title>bespectacledcolfer replied to your post: I don’t really post stuff here much anymore.  I&amp;#8230;
Miss...</title><description>&lt;div class="hide_overflow"&gt;&lt;a href="http://bespectacledcolfer.tumblr.com/"&gt;bespectacledcolfer&lt;/a&gt; replied to your &lt;a href="http://joyfultyrannous.tumblr.com/post/27784865382"&gt;post&lt;/a&gt;&lt;span&gt;:&lt;/span&gt; &lt;em&gt;&lt;a href="http://joyfultyrannous.tumblr.com/post/27784865382"&gt;I don’t really post stuff here much anymore.  I&amp;#8230;&lt;/a&gt;&lt;/em&gt;&lt;/div&gt;
&lt;blockquote&gt;Miss your face. :(&lt;/blockquote&gt;
&lt;p&gt;Miss you too!&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/27788210324</link><guid>http://joyfultyrannous.tumblr.com/post/27788210324</guid><pubDate>Sun, 22 Jul 2012 18:14:42 -0400</pubDate><category>bespectacledcolfer</category></item><item><title>So you're the writer of Down Where the World is Ending? I just have to say, whatever anon hate you are getting is completely ridiculous and all those chicken-shit anons should have their internet rights revoked. I'm a huge fan of Down Where the World is Ending, as well as several of your other fics. Don't let random anons get you down, they're just that - anons. All I know is whatever you do decide to write, WIPs or new fics altogether, I will most certainly be reading them. :)</title><description>&lt;p&gt;Last year I got about 50 or 60 “Go kill yourself” and “I hate you go die” messages, as well as some death threats and some overall nastiness.  I also got them on my livejournal, on my youtube channel, and on my twitter.&lt;/p&gt;
&lt;p&gt;I wound up moving to a new internet identity, which only a few people know is me. &lt;/p&gt;
&lt;p&gt;If people really want to know where I do most of my blogging now, please contact me privately, and I’ll send you my new tumblr/LJ/twitter/youtube(no videos up there yet)/AO3 account.&lt;/p&gt;

&lt;p&gt;I still post here occasionally, especially in reference to the fanfiction I’ve already published under the name “Joyful.”  But I’m not really active as “Joyful” anymore.  Too much hate in too many fandoms.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/27787968614</link><guid>http://joyfultyrannous.tumblr.com/post/27787968614</guid><pubDate>Sun, 22 Jul 2012 18:10:00 -0400</pubDate><category>mskayladenny</category></item><item><title>I don&amp;#8217;t really post stuff here much anymore.  I should.  I think I just got too drained out...</title><description>&lt;p&gt;I don&amp;#8217;t really post stuff here much anymore.  I should.  I think I just got too drained out with all the anon hate.  I&amp;#8217;m also not really in Glee fandom anymore.  And I&amp;#8217;m not writing much right now.&lt;/p&gt;
&lt;p&gt;I want to finish my WIPs, especially Four Square and Pretty Girl, but it&amp;#8217;s really hard, you know?&lt;/p&gt;
&lt;p&gt;I&amp;#8217;m also trying to write some original stuff.&lt;/p&gt;
&lt;p&gt;I&amp;#8217;ve been sucking as a mod lately.  The Glee Crossover meme has fallen into disuse, and I haven&amp;#8217;t been very active in the Glee Angst meme.&lt;/p&gt;
&lt;p&gt;The anon hate really gets to me sometimes.  I&amp;#8217;ve mainly reverted to lurker status in most of my fandoms.&lt;/p&gt;
&lt;p&gt;I&amp;#8217;m sorry.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/27784865382</link><guid>http://joyfultyrannous.tumblr.com/post/27784865382</guid><pubDate>Sun, 22 Jul 2012 17:22:19 -0400</pubDate></item><item><title>Down Where the World is Ending</title><description>&lt;p&gt;&lt;a class="tumblr_blog" href="http://mskayladenny.tumblr.com/post/27573924456/down-where-the-world-is-ending"&gt;mskayladenny&lt;/a&gt;:&lt;/p&gt;
&lt;blockquote&gt;
&lt;p&gt;A fic by a wonderful author I just discovered, Joyful. I would really like to find them on Tumblr!&lt;/p&gt;
&lt;p&gt;MAJOR CHARACTER DEATH, but oh my gosh, despite the complete sadness this fic put me on, it’s extremely good and I highly recommend it.&lt;/p&gt;
&lt;p&gt;Obviously, there’s a nice mix of accurate character humor thrown in as well.&lt;/p&gt;
&lt;p&gt;Author’s Summary: &lt;/p&gt;
&lt;p&gt;&lt;em&gt;Mama Hummel had Huntington’s Disease, and the Hudson-Hummel clan has to deal with Kurt’s inevitable early demise, because he inherited it from his mother.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;Here’s the link: &lt;a href="http://archiveofourown.org/works/172254?view_adult=true"&gt;&lt;a href="http://archiveofourown.org/works/172254?view_adult=true"&gt;http://archiveofourown.org/works/172254?view_adult=true&lt;/a&gt;&lt;/a&gt;&lt;/p&gt;
&lt;/blockquote&gt;
&lt;p&gt;I&amp;#8217;m here, but I don&amp;#8217;t post very often anymore.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/27784333944</link><guid>http://joyfultyrannous.tumblr.com/post/27784333944</guid><pubDate>Sun, 22 Jul 2012 17:13:52 -0400</pubDate></item><item><title>ucsdhealthsciences:

A human neuron. UC San Diego scientists...</title><description>&lt;img src="http://25.media.tumblr.com/tumblr_m70eyhYFop1qievavo1_500.jpg"/&gt;&lt;br/&gt;&lt;br/&gt;&lt;p&gt;&lt;a class="tumblr_blog" href="http://ucsdhealthsciences.tumblr.com/post/26991636370/a-human-neuron-uc-san-diego-scientists-have"&gt;ucsdhealthsciences&lt;/a&gt;:&lt;/p&gt;
&lt;blockquote&gt;
&lt;p&gt;&lt;em&gt;A human neuron. UC San Diego scientists have identified a pair of proteins that help clear away other misfolded proteins responsible for the progressive degeneration of brain cells in Huntington’s disease.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;a href="http://health.ucsd.edu/news/releases/Pages/2012-07-11-proteins-and-huntingtons-disease.aspx" title="Two Proteins Offer a "Clearer" Way to Treat Huntington's Disease"&gt;Two Proteins Offer a “Clearer” Way to Treat Huntington’s Disease&lt;br/&gt;&lt;/a&gt;&lt;em&gt;Pair helps remove and prevent misfolding of proteins that cause neurodegeneration&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause the progressive, deadly neurodegeneration of Huntington’s disease (HD).&lt;br/&gt;  &lt;br/&gt;The findings explain a fundamental aspect of how HD wreaks havoc within cells and provides “clear, therapeutic opportunities,” said principal investigator Albert R. La Spada, MD, PhD, professor of cellular and molecular medicine, chief of the Division of Genetics in the Department of Pediatrics and associate director of the Institute for Genomic Medicine at UC San Diego.&lt;/p&gt;
&lt;p&gt;“We think the implications are significant,” said La Spada. “It’s a lead we can vigorously pursue, not just for Huntington’s disease, but also for similar neurodegenerative conditions like Parkinson’s disease and maybe even Alzheimer’s disease.”&lt;/p&gt;
&lt;p&gt;In HD, an inherited mutation in the huntingtin (htt) gene results in misfolded htt proteins accumulating in certain central nervous system cells, leading to progressive deterioration of involuntary movement control, cognitive decline and psychological problems. More than 30,000 Americans have HD. There are no effective treatments currently to either cure the disease or slow its progression.&lt;/p&gt;
&lt;p&gt;La Spada and colleagues focused on a protein called PGC-1alpha, which helps regulate the creation and operation of mitochondria, the tiny organelles that generate the fuel required for every cell to function.&lt;/p&gt;
&lt;p&gt;“It’s all about energy,” La Spada said. “Neurons have a constant, high demand for it. They’re always on the edge for maintaining adequate levels of energy production. PGC-1alpha regulates the function of transcription factors that promote the creation of mitochondria and allow them to run at full capacity.”&lt;/p&gt;
&lt;p&gt;Previous studies by La Spada and others discovered that the mutant form of the htt gene interfered with normal levels and functioning of PGC-1alpha. “This study confirms that,” La Spada said. More surprising was the discovery that elevated levels of PGC-1alpha in a mouse model of HD virtually eliminated the problematic misfolded proteins.&lt;/p&gt;
&lt;p&gt;&lt;a href="http://health.ucsd.edu/news/releases/Pages/2012-07-11-proteins-and-huntingtons-disease.aspx" title="Two Proteins Offer a "Cleare" Way to Treat Huntington's Disease"&gt;More here&lt;/a&gt;&lt;/p&gt;
&lt;/blockquote&gt;
&lt;p&gt;This is awesome and relevant and makes me happy.&lt;/p&gt;</description><link>http://joyfultyrannous.tumblr.com/post/27002616848</link><guid>http://joyfultyrannous.tumblr.com/post/27002616848</guid><pubDate>Wed, 11 Jul 2012 17:36:52 -0400</pubDate></item><item><title>Photo</title><description>&lt;img src="http://25.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o3_250.png"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://25.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o4_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://25.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o5_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://25.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o6_r2_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://24.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o7_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://24.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o8_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://25.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o9_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;&lt;img src="http://25.media.tumblr.com/tumblr_m6s2t515nQ1r79z72o10_250.gif"/&gt;&lt;br/&gt; &lt;br/&gt;</description><link>http://joyfultyrannous.tumblr.com/post/26731625017</link><guid>http://joyfultyrannous.tumblr.com/post/26731625017</guid><pubDate>Sat, 07 Jul 2012 21:17:42 -0400</pubDate></item></channel></rss>
